deCODE ProstateCancer™

A novel test detecting the most comprehensive set of validated genetic risk factors for prostate cancer. The test identifies 6% of men of European descent who are at more than double the average lifetime risk, 12% of African-American men who have between 1.5 fold and threefold increased risk, and 7% of East Asian men who have between two to eightfold increased risk. Test results, along with other risk factors, can help to inform and optimize screening and early detection.

Screening and prevention

How deCODE ProstateCancer™ can help.

Genetic risk and screening

The American Urology Association (AUA) recommends that men 40 and over should be offered baseline assessment for risk of prostate cancer. deCODE ProstateCancer™ is a one time test that measures genetic risk of prostate cancer and can thereby help to establish an individual’s baseline risk. This brings genetic risk into the discussion between men and their physicians regarding whether, when and how frequently to screen for prostate cancer going forward.

Informing the decision to biopsy

Having the most complete picture of individual risk is fundamental to making an informed decision whether to proceed to biopsy. deCODE ProstateCancer™ provides novel information that, together with other risk factors, clinical examination and PSA scores, contributes to a comprehensive risk profile with which to consider the options.

References

1. Gudmundsson, Julius et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008 Mar;40(3):281-3. Epub 2008 Feb 10. PMID: 18264098

2. Liu H et al. Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate. 2010 Aug 5. PMID: 20690139

3. Eeles, Rosalind A et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct;41(10):1116-21. Epub 2009 Sep 20. PMID: 19767753

4. Gudmundsson, Julius et al. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet. 2009 Oct;41(10):1122-6. Epub 2009 Sep 20. PMID: 19767754

5. Kote-Jarai, Zsofia et al. Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2052-61. PMID: 18708398

6. Waters, Kevin M et al. Generalizability of associations from prostate cancer genome-wide association studies in multiple populations. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1285-9. Epub 2009 Mar 24. PMID: 19318432

7. Rafnar, Thorunn et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet. 2009 Feb;41(2):221-7. Epub 2009 Jan 18. PMID: 19151717

8. Thomas, Gilles et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008 Mar;40(3):310-5. Epub 2008 Feb 10. PMID: 18264096

9. Prokunina-Olsson, Ludmila et al. Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2. Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1349-55. Epub 2010 Apr 20. PMID: 20406958

10. Stevens, Victoria L et al. HNF1B and JAZF1 genes, diabetes, and prostate cancer risk. Prostate. 2010 May 1;70(6):601-7. PMID: 19998368

11. Gudmundsson, Julius et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet. 2007 May;39(5):631-7. Epub 2007 Apr 1. PMID: 17401366

12. Amundadottir, Laufey T et al. A common variant associated with prostate cancer in European and African populations. Nat Genet. 2006 Jun;38(6):652-8. Epub 2006 May 7. PMID: 16682969

13. Freedman, Matthew L et al. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14068-73. Epub 2006 Aug 31. PMID: 16945910

14. Haiman, Christopher A et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007 May;39(5):638-44. Epub 2007 Apr 1. PMID: 17401364

15. Yeager, Meredith et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet. 2007 May;39(5):645-9. Epub 2007 Apr 1. PMID: 17401363

16. Schumacher, Fredrick R et al. A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res. 2007 Apr 1;67(7):2951-6. PMID: 17409400

17. Severi, Gianluca et al. The common variant rs1447295 on chromosome 8q24 and prostate cancer risk: results from an Australian population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):610-2. PMID: 17372260

18. Suuriniemi, Miia et al. Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):809-14. PMID: 17416775

19. Wang, Liang et al. Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. Cancer Res. 2007 Apr 1;67(7):2944-50. PMID: 17409399

20. Zheng, S Lilly et al. Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans. J Natl Cancer Inst. 2007 Oct 17;99(20):1525-33. Epub 2007 Oct 9. PMID: 17925536

21. Yeager, Meredith et al. Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet. 2009 Oct;41(10):1055-7. Epub 2009 Sep 20. PMID: 19767755

22. Beuten, Joke et al. Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men. Carcinogenesis. 2009 Aug;30(8):1372-9. Epub 2009 Jun 15. PMID: 19528667

23. Wokolorczyk, Dominika et al. A range of cancers is associated with the rs6983267 marker on chromosome 8. Cancer Res. 2008 Dec 1;68(23):9982-6. PMID: 19047180

24. Tan, Ying-Cai et al. Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2431-5. PMID: 18768513

25. Cussenot, Olivier et al. Effect of genetic variability within 8q24 on aggressiveness patterns at diagnosis and familial status of prostate cancer. Clin Cancer Res. 2008 Sep 1;14(17):5635-9. PMID: 18765558

26. Terada, Naoki et al. Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population. Prostate. 2008 Nov 1;68(15):1689-95. PMID: 18726982

27. Beebe-Dimmer, Jennifer L et al. Chromosome 8q24 markers: risk of early-onset and familial prostate cancer. Int J Cancer. 2008 Jun 15;122(12):2876-9. PMID: 18360876

28. Cheng, Iona et al. 8q24 and prostate cancer: association with advanced disease and meta-analysis. Eur J Hum Genet. 2008 Apr;16(4):496-505. Epub 2008 Jan 30. PMID: 18231127

29. Al Olama, Ali Amin et al. Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet. 2009 Oct;41(10):1058-60. Epub 2009 Sep 20. PMID: 19767752

30. Xu, Jianfeng et al. Prostate cancer risk associated loci in African Americans. Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2145-9. Epub 2009 Jun 23. PMID: 19549807

31. Wang Y et al. Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men’s health study. Prostate. 2010 Aug 17. PMID: 20717903

32. Benford, Marnita L et al. 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study. BMC Cancer. 2010 Jun 28;10:334. PMID: 20584312

33. Kim ST et al. Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation. Prostate. 2010 Jun 16. PMID: 20564319

34. Chen, Marcelo et al. Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men. Prostate. 2010 Apr 1;70(5):502-7. PMID: 19908238

35. Sun, Jielin et al. Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients. Prostate. 2008 Apr 1;68(5):489-97. PMID: 18213635

36. Robbins, Christiane et al. Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus. Genome Res. 2007 Dec;17(12):1717-22. Epub 2007 Oct 31. PMID: 17978284

37. Yamada, Hiroki et al. Replication of prostate cancer risk loci in a Japanese case-control association study. J Natl Cancer Inst. 2009 Oct 7;101(19):1330-6. Epub 2009 Sep 2. PMID: 19726753

38. Xu, Bin et al. A functional polymorphism in MSMB gene promoter is associated with prostate cancer risk and serum MSMB expression. Prostate. 2010 Jul 1;70(10):1146-52. PMID: 20333697

39. Lou, Hong et al. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7933-8. Epub 2009 Apr 21. PMID: 19383797

40. Fitzgerald, Liesel M et al. Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features. Clin Cancer Res. 2009 May 1;15(9):3231-7. Epub 2009 Apr 14. PMID: 19366831

41. Camp, Nicola J et al. Replication of the 10q11 and Xp11 prostate cancer risk variants: results from a Utah pedigree-based study. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1290-4. Epub 2009 Mar 31. PMID: 19336566

42. Chang, Bao-Li et al. Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk. Hum Mol Genet. 2009 Apr 1;18(7):1368-75. Epub 2009 Jan 19. PMID: 19153072

43. Hooker, Stanley et al. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. Prostate. 2010 Feb 15;70(3):270-5. PMID: 19902474

44. Gudmundsson, Julius et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007 Aug;39(8):977-83. Epub 2007 Jul 1. PMID: 17603485

45. Helfand, Brian T et al. Pathological outcomes associated with the 17q prostate cancer risk variants. J Urol. 2009 Jun;181(6):2502-7. Epub 2009 Apr 16. PMID: 19371897

46. Elliott, Katherine S et al. Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One. 2010 May 28;5(5):e10858. PMID: 20526366

47. Sun, Jielin et al. Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet. 2008 Oct;40(10):1153-5. Epub 2008 Aug 31. PMID: 18758462

48. Lu, Lingyi et al. Fine-mapping and family-based association analyses of prostate cancer risk variants at Xp11. Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2132-6. Epub 2009 Jun 23. PMID: 19549809

49. Eeles RA, et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet 2008;40:316-21.

50. Takata, Ryo et al. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet. 2010 Sep;42(9):751-4. PMID: 20676098

51. Liu, Hong et al. Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate. 2011 Feb 1;71(2):209-24. PMID: 20690139

52. Chang, Bao-Li et al. Validation of genome-wide prostate cancer associations in men of African descent. Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):23-32. PMID: 21071540

53. Johns LE, and Houlston RS. BJU Int 2003;91:789-94.

54. SEER web site (http://seer.cancer.gov/statfacts/html/prost.html)

55. Schroder, F.H., Hugosson, J., Roobol, M.J., et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med, 360: 11320-8, 2009

56. Andriole, G.L., Grubb, R.L., Buys, S.S., et al. Mortality results from a randomized prostatecancer screening trial. N Engl J Med, 360: 1310-19, 2009