deCODE Glaucoma™

A novel DNA-based test that assesses risk for exfoliation glaucoma. Individuals testing positive are at 2.4-times the population average risk of developing exfoliation glaucoma.

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Screening and prevention

How deCODE Glaucoma™ can help.

deCODE Glaucoma™ identifies those who are at increased genetic risk of developing open angle glaucoma

The deCODE Glaucoma™ risk results are independent of and complementary to other known risk factors such as family history of glaucoma or elevated eye pressure.

Those who test positive may derive greatest benefit from regular eye exams, with the aim of detecting more disease earlier and treating it to slow progression and preserve vision.

References

1. Thorleifsson, Gudmar et al. Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science. 2007 Sep 7;317(5843):1397-400. Epub 2007 Aug 9. PMID: 17690259

2. Fingert, John H et al. LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States. Am J Ophthalmol. 2007 Dec;144(6):974-975. PMID: 18036875

3. Hewitt, Alex W et al. Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people. Hum Mol Genet. 2008 Mar 1;17(5):710-6. Epub 2007 Nov 23. PMID: 18037624

4. Mossbock, Georg et al. Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population. Mol Vis. 2008 May 9;14:857-61. PMID: 18483563

5. Fan, Bao Jian et al. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity. BMC Med Genet. 2008 Feb 6;9:5. PMID: 18254956

6. Fuse, Nobuo et al. Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese. Mol Vis. 2008 Jul 21;14:1338-43. PMID: 18648524

7. Lee, Kelvin Y C et al. Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese. Mol Vis. 2009 Jun 4;15:1120-6. PMID: 19503743

8. Ozaki, Mineo et al. Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3976-80. Epub 2008 Apr 30. PMID: 18450598

9. Chen, Ling et al. Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population. Mol Vis. 2009 Nov 14;15:2349-57. PMID: 19936304

10. Hayashi, Hisako et al. Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population. Am J Ophthalmol. 2008 Mar;145(3):582-585. Epub 2008 Jan 16. PMID: 18201684

11. Aragon-Martin, Jose A et al. Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. Mol Vis. 2008 Mar 17;14:533-41. PMID: 18385788

12. Yang, Xian et al. Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort. Cell Cycle. 2008 Feb 15;7(4):521-4. PMID: 18287813

13. Challa, Pratap et al. Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma. Mol Vis. 2008 Jan 29;14:146-9. PMID: 18334928

14. Ramprasad, Vedam Lakshmi et al. Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India. Mol Vis. 2008 Feb 9;14:318-22. PMID: 18334947

15. Pasutto, Francesca et al. Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1459-63. PMID: 18385063

16. Williams, Susan E I et al. Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population. Mol Vis. 2010 Apr 21;16:705-12. PMID: 20431720

17. Chen, Haoyu et al. Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma. Mol Vis. 2010 Feb 6;16:167-77. PMID: 20142848

18. Wolf, Christiane et al. Lysyl oxidase-like 1 gene polymorphisms in German patients with normal tension glaucoma, pigmentary glaucoma and exfoliation glaucoma. J Glaucoma. 2010 Feb;19(2):136-41. PMID: 19373106

19. Lemmela, Susanna et al. Association of LOXL1 gene with Finnish exfoliation syndrome patients. J Hum Genet. 2009 May;54(5):289-97. Epub 2009 Apr 3. PMID: 19343041

20. Tanito, Masaki et al. LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. Mol Vis. 2008;14:1898-905. Epub 2008 Oct 27. PMID: 18958304

21. Mabuchi, Fumihiko et al. Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome. Mol Vis. 2008 Jul 14;14:1303-8. PMID: 18636115

22. Mori, Kazuhiko et al. LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population. Mol Vis. 2008 Jun 5;14:1037-40. PMID: 18552979

23. Arnarsson, Arsaell Mar. Epidemiology of exfoliation syndrome in the Reykjavik Eye Study. Acta Ophthalmol. 2009 Dec;87 Thesis 3:1-17. PMID: 20017735

24. Arnarsson, A.M. et al. Pseudoexfoliation in the reykjavik eye study: five-year incidence and changes in related ophthalmologic variables. Am J Ophthalmol, 2009 Aug;148(2):291-7. Epub 2009 May 9.

25. Jeng, S.M. et al. The risk of glaucoma in pseudoexfoliation syndrome. J Glaucoma, 2007 Jan;16(1):117-21.