deCODE Complete
Analyzes risk factors for more than fifty common diseases and several traits, including all of those for which deCODEhealth offers individual disease tests. deCODE Complete focuses on medical conditions that can either be better prevented through altered lifestyle or that have better treatment outcomes if detected early. It is the most comprehensive genetic scan available for evaluating risk of common diseases. It is not generally reimbursable.
Diseases and conditions covered by the deCODE Complete Scan:
Abdominal Aortic Aneurysm, ABO Blood Types, Age Related Macular Degeneration, Alcohol Flush Reaction, Alzheimer’s Disease, Asthma, Atrial Fibrillation, Basal Cell Carcinoma, Bitter Taste Perception, Bladder Cancer, Brain Aneurysm, Brain Cancer-Glioma, Breast Cancer, Celiac Disease, Chronic Kidney Disease, Chronic Lymphocytic Leukemia, Chronic Obstructive Pulmonary Disease, Clopidogrel Response, Colorectal Cancer, Crohn’s Disease, Essential Tremor, Exfoliation Glaucoma, Eye Color, Gallstones, Gout, Heart Attack, Hemochromatosis, Hypertension, Kidney Stones, Lactose Intolerance, Lung Cancer, Male Pattern Baldness, Multiple Sclerosis, Nicotine Dependence, Obesity, Ovarian Cancer, Pancreatic Cancer, Peripheral Arterial Disease, Prostate Cancer, Psoriasis, Restless Legs Syndrome, Rheumatoid Arthritis, Statin Induced Myopathy, Systemic Lupus Erythematosus, Testicular Cancer, Thyroid Cancer, Type 1 Diabetes, Type 2 Diabetes, Ulcerative Colitis, Venous Thromboembolism, Warfarin Metabolism.
Chronic Obstructive Pulmonary Disease
Smoking is the major environmental cause of COPD, but genetic factors also influence the risk of developing this disease.
Many of those who are at risk for COPD may not realize it.
deCODEhealth analyzes your patients’ DNA and provides you with a personalized risk assesment for developing COPD.
Knowing your patients’ risk of developing COPD can increase your awareness and empower you to take preventive steps to protect their lungs.
deCODEhealth helps you breathe easy.
COPD is a group of lung diseases
COPD is one of the most common lung disorders in adults. It is one of the leading causes of death in developed nations and affects both men and women. The term COPD refers to a group of lung diseases that cause inflammation and excess mucus in the airways of the lungs (called bronchi and bronchioles), leading to obstructed air flow from the lungs. As the disease progresses, people find it harder to remain active due to shortness of breath.
Emphysema and chronic bronchitis are the two main types of COPD diseases
Emphysema and chronic bronchitis are the two main types of COPD diseases. In some cases both diseases may be present at the same time.
In emphysema there is damage to the walls of the air sacs or alveoli in the lungs which results in a smaller total number of air sacs. Fewer air sacs mean that the lungs are not able to transfer oxygen into the bloodstream as efficiently, nor get rid of carbon dioxide properly. The damaged lungs lose their elasticity making breathing more difficult.
In chronic bronchitis there is inflammation of the main air passages (bronchi) to the lungs resulting in a long lasting cough. When the airways become swollen they produce more mucus, making breathing more difficult. COPD can also refer to damage caused by chronic asthmatic bronchitis.
Smoking is the major risk factor for COPD, but genetic factors contribute significantly
Smoking is the main environmental risk factor of COPD and accounts for 80% to 90% of COPD-related deaths. However, 10-20% of COPD patients have never smoked and only a fraction of smokers ever develop COPD. Indeed, genetic and other environmental factors than smoking, also influence the risk of developing COPD. Studies have demonstrated that decreased lung function as measured by so-called spirometry tests runs in families. COPD has also been found to cluster within families. These findings show that genetic factors affect both the level of lung function and susceptibility to develop COPD.
deCODEhealth calculates your patients’ genetic risk of developing COPD
The deCODE Complete Scan identifies validated COPD risk variants and uses them to provide a personalized interpretation of the associated genetic risk for COPD. The number of variants included in the deCODE Complete Scan for each ethnic group are listed in the table below.
| Number of Variants Measured | |
|---|---|
| European ancestry | 5 |
| East Asian ancestry | 1 |
At present, the necessary scientific information to interpret the genetic risk for individuals of other ethnicities is not available. This information will be added as soon as it becomes available and we are assured of its quality.
This content was last reviewed on February 20, 2012.