deCODE Complete
Analyzes risk factors for more than fifty common diseases and several traits, including all of those for which deCODEhealth offers individual disease tests. deCODE Complete focuses on medical conditions that can either be better prevented through altered lifestyle or that have better treatment outcomes if detected early. It is the most comprehensive genetic scan available for evaluating risk of common diseases. It is not generally reimbursable.
Diseases and conditions covered by the deCODE Complete Scan:
Abdominal Aortic Aneurysm, ABO Blood Types, Age Related Macular Degeneration, Alcohol Flush Reaction, Alzheimer’s Disease, Asthma, Atrial Fibrillation, Basal Cell Carcinoma, Bitter Taste Perception, Bladder Cancer, Brain Aneurysm, Brain Cancer-Glioma, Breast Cancer, Celiac Disease, Chronic Kidney Disease, Chronic Lymphocytic Leukemia, Chronic Obstructive Pulmonary Disease, Clopidogrel Response, Colorectal Cancer, Crohn’s Disease, Essential Tremor, Exfoliation Glaucoma, Eye Color, Gallstones, Gout, Heart Attack, Hemochromatosis, Hypertension, Kidney Stones, Lactose Intolerance, Lung Cancer, Male Pattern Baldness, Multiple Sclerosis, Nicotine Dependence, Obesity, Ovarian Cancer, Pancreatic Cancer, Peripheral Arterial Disease, Prostate Cancer, Psoriasis, Restless Legs Syndrome, Rheumatoid Arthritis, Statin Induced Myopathy, Systemic Lupus Erythematosus, Testicular Cancer, Thyroid Cancer, Type 1 Diabetes, Type 2 Diabetes, Ulcerative Colitis, Venous Thromboembolism, Warfarin Metabolism.
Chronic Kidney Disease
Early detection can help prevent the progression of kidney disease to kidney failure.
High risk groups include people with diabetes, hypertension and a family history of kidney disease.
The deCODE Complete Scan analyzes your patients’ DNA and provides you with a personalized risk assessment for their Chronic Kidney Disease risk.
Knowing your patients’ risk for Chronic Kidney Disease can increase your awareness and empower you to take preventive steps to protect their kidneys
The kidneys keep the blood chemically balanced
The kidneys are a pair of bean-shaped organs located on either side of the spine, just below the rib cage. Each kidney contains about a million tiny blood-filtering units called nephrons. Each nephron contains a glomerulus, that filters and conveys waste from the blood and into the urine. Neprhons also carry a small blood vessel that returns the filtered blood back to the body´s circulatory system. It is in this way that the kidneys fulfill their primary function – to remove waste products and excess water from the blood and deliver them to the bladder as urine. The kidneys also help control blood pressure and regulate red blood cell production in the bone marrow.
Chronic Kidney Disease is a result of damaged nephrons
Chronic Kidney Disease typically develops as a result of other common diseases, primarily diabetes, high blood pressure and obesity. These diseases gradually damage the kidney´s nephrons (and their glomeruli), such that they lose their capacity to filter waste and toxins from the blood and leak essential blood proteins into the urine. Kidney function is reflected by the so-called glomerular filtration rate (GFR), which decreases gradually and constantly in Chronic Kidney Disease. However, perceptible symptoms may not become apparent until after years or even decades of declining kidney function. A widely used surrogate measure of the GFR is the concentration of the protein creatinine in blood, which increases as kidney function declines.
Early diagnosis of Chronic Kidney Disease is crucial
In advanced stages, Chronic Kidney Disease can ultimately lead to complete kidney failure and the need for dialysis or kidney transplantation. People with Chronic Kidney Disease also have an increased risk of developing cardiovascular diseases and side-effects to various medications. As a result, early diagnosis and treatment are crucial to slow down kidney damage and concomitant health problems.
Chronic Kidney Disease is a growing health problem
The Centers for Disease Control (CDC) in the U.S. has reported that 16.8% of all adults above the age of 20 years have Chronic Kidney Disease. This represents a 16% increase from the previous decade, making the disease a growing problem. This increase is partly explained by the increasing prevalence of diabetes and hypertension. Chronic Kidney Disease is most prevalent among individuals above 60 years of age (39.4%) and more common among Hispanics, African Americans, Asians or Pacific Islanders, and Native Americans, than people of European descent.
Genetic variants are associated with risk of Chronic Kidney Disease
Not everyone has the same risk of developing Chronic Kidney Disease. Research suggests that this disease has a strong familial component. A common genetic variant (rs4293393-T) is known to be associated with increased risk of Chronic Kidney Disease. This variant is positioned next to the UMOD gene on chromosome 16p12, a gene that encodes the protein uromodulin (sometimes called the Tamm-Horsfall protein), which is the most abundant protein in urine.
deCODEhealth calculates your patients’ genetic risk for Chronic Kidney Disease
Variants associated with Chronic Kidney Disease and included in the deCODEme Genetic Scan are listed in the table below for each ethnic group. These variants are used to provide our customers with a personalized interpretation of their genetic risk for developing Chronic Kidney Disease. See what your genetic test results could look like.
| Number of Variants Measured | |
|---|---|
| European ancestry | 1 |
At present, the necessary scientific information to interpret the genetic risk for individuals of other ethnicities is not available. This information will be added as soon as it becomes available and we are assured of its quality.
At present, the necessary scientific information to interpret the genetic risk for customers of other ethnicities is not available. This information will be added as soon as it becomes available and we are assured of its quality.
This content was last reviewed on February 15, 2012.