deCODE Complete
Analyzes risk factors for more than fifty common diseases and several traits, including all of those for which deCODEhealth offers individual disease tests. deCODE Complete focuses on medical conditions that can either be better prevented through altered lifestyle or that have better treatment outcomes if detected early. It is the most comprehensive genetic scan available for evaluating risk of common diseases. It is not generally reimbursable.
Diseases and conditions covered by the deCODE Complete Scan:
Abdominal Aortic Aneurysm, ABO Blood Types, Age Related Macular Degeneration, Alcohol Flush Reaction, Alzheimer’s Disease, Asthma, Atrial Fibrillation, Basal Cell Carcinoma, Bitter Taste Perception, Bladder Cancer, Brain Aneurysm, Brain Cancer-Glioma, Breast Cancer, Celiac Disease, Chronic Kidney Disease, Chronic Lymphocytic Leukemia, Chronic Obstructive Pulmonary Disease, Clopidogrel Response, Colorectal Cancer, Crohn’s Disease, Essential Tremor, Exfoliation Glaucoma, Eye Color, Gallstones, Gout, Heart Attack, Hemochromatosis, Hypertension, Kidney Stones, Lactose Intolerance, Lung Cancer, Male Pattern Baldness, Multiple Sclerosis, Nicotine Dependence, Obesity, Ovarian Cancer, Pancreatic Cancer, Peripheral Arterial Disease, Prostate Cancer, Psoriasis, Restless Legs Syndrome, Rheumatoid Arthritis, Statin Induced Myopathy, Systemic Lupus Erythematosus, Testicular Cancer, Thyroid Cancer, Type 1 Diabetes, Type 2 Diabetes, Ulcerative Colitis, Venous Thromboembolism, Warfarin Metabolism.
ABO blood types
The deCODE Complete Scan analyzes your patients’ DNA and identifies which combination of the three ABO alleles are carried on chromosome 9 and therefore which blood type they are likely to have.
Please note that the results of the deCODE Complete Scan cannot replace a traditional ABO blood typing test used for medical procedures.
deCODE your patients’ genetically determined ABO blood type with deCODEhealth
All human blood is similar, but some blood types are more similar than others
In most respects all humans have very similar blood. As a result, it is possible to transfer blood from one human to another. This procedure, called blood transfusion, is now routine and safe in modern medical practice, and has saved the lives of countless people since being widely adopted in the 1940s. However, you cannot receive blood from just anyone. Your blood must be compatible with that of the blood donor.
ABO blood types are determined by red blood cell antigens
There are four different ABO blood types, named A, B, O and AB. Your ABO blood type depends on which kind of glycoprotein or antigen is found on the outside of your blood cells. These glycoproteins come in three forms and are referred to as A, B and O.
The gene that determines ABO blood type is found on chromosome nine
The gene that determines ABO blood type is found on chromosome 9 and is called ABO glycosyltransferase. In the simplest terms, this gene may be said to come in three different forms, that is, it has three different alleles. These alleles are also named A, B and O, because each is responsible for the production of its namesake glycoprotein (antigen). It is therefore the combination of alleles that are inherited from your parents that determines which glycoproteins (antigens) are found on your blood cells and thereby your ABO blood type.
Six possible allele combinations determine four distinct ABO blood types
The six possible distinct combinations of alleles (and antigens), and the four distinct blood types they determine, are shown below:
| Combination of ABO alleles | ABO antigens on the surface of blood cells | ABO blood type | |
|---|---|---|---|
| 1. | AA | A | A |
| 2. | AO | A and O | |
| 3. | BB | B | B |
| 4. | BO | B and O | |
| 5. | AB | A and B | AB |
| 6. | OO | O | O |
The deCODE Complete Scan identifies which combination of the three ABO alleles are carried on chromosome 9 and therefore which blood type one is likely to have. At the present time, sufficient predictive data is only available for customers of European ancestry.
Please note that the results of the deCODEhealth scan cannot replace a traditional ABO blood typing test that is used for critical medical procedures such as blood transfusion or organ transplantation. What we provide here is a prediction of your patients’ ABO blood type based on the genetic variants included in the deCODE Complete Scan.
Scientific references
- Yip SP. (2002). Sequence variation at the human ABO locus. Annals of Human Genetics. Jan;66(Pt 1):1-27.
- Seattle SNPs Variation Discovery Resource – ABO:ABO blood group.
This content was last reviewed on February 21, 2011.