deCODE Cardio

deCODE Intracranial Aneurysm test

Three SNPs identify 25% of the population that has between 1.3 to 2.0-fold average risk of IA.

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The deCODE Cardio Scan detects the same risk factors and markers included in our individual tests for:

Atrial Fibrillation (deCODE AF™),
Clopidogrel Metabolizing Status (deCODE Clopidogrel™),
Heart Attack (deCODE MI™) and
Type 2 Diabetes (deCODE T2™).

together with:

Abdominal Aortic Aneurysm, Intracranial Aneurysm and Venous Thromboembolism.

Intracranial Aneurysm

Screening and Prevention

How the deCODE Intracranial Aneurysm test can help.

Understanding you patient’s risk of IA is fundamental to the decision on whether to screen. The risk conferred by the deCODE IA markers is largely independent of family history, meaning that you can multiply the result of the deCODE test by the family history risk to yield a more comprehensive risk score.

The deCODEC IA markers are three SNPs (rs10757278, rs10958409, rs9298506) on chromosomes 8 and 9 associated with risk of IA.

For individuals of European descent, the risk range of the test is 0.397- to 2.53-times population average risk. Approximately 25% of the population will receive results of between 1.3- and 2.0-fold average risk, and about 1% will receive a result of 2.53.

For East Asians, validation is available only for the 9p21 marker (rs10757278). Those homozygous for the risk allele (about 43% of East Asians) have an approximately 20% increase in risk for IA compared to the average in East Asians.

The associated risk for IA to markers has been validated in multiple cohorts comprising the total of about 5,000 patients and 31,000 controls.

This content was last reviewed on January 26, 2011.