deCODE Cancer

deCODE Colorectal Cancer test

Identifies approximately 20% of people of European and East Asian descent who are at substantially increased risk of CRC.

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The deCODE Cancer Scan detects the same risk factors and markers included in our individual tests for:

Breast Cancer (deCODE BreastCancer™) and
Prostate Cancer (deCODE ProstateCancer™)

together with:

Basal Cell Carcinoma, Bladder Cancer, Colorectal Cancer, Lung Cancer, Ovarian Cancer, Testicular Cancer and Thyroid Cancer.

Colorectal Cancer

Screening and prevention

How the deCODE Colorectal Cancer test can help.

The deCODE Cancer CRC risk markers can identify those who have an extra reason to follow the ACA guidelines of colorectal cancer screening after the age of 50.

The relative risk conferred by these markers can be used to multiply whatever other identified risk the individual is found to have, including the two-fold increase in risk conferred by having a close relative with the disease.

Having as complete a picture as possible of individual risk, including genetic risk, is always important when considering screening and intervention options.

The deCODE Cancer markers for Colorectal cancer are 8 SNPs that have been associated with the risk of people of European descent of developing cancer in the colon and rectum.

For East Asians scientific information is only available for 2 markers (rs6983267 and rs4939827), which identify the 20% of the East Asian population who have genotype combinations conveying 1.2 to 1.48 their general population risk.

The American Cancer Society recommends that, beginning at age 50, all individuals should follow 1 of 5 testing schedules for possible early detection of colorectal cancer.

The relative genetic risk results of the deCODE Colorectal Cancer test is largely independent of family history. This means that the risk identified by the test is in addition to, and can be used to multiply, the two fold increase in risk of people having a close relative with colorectal cancer.

This content was last reviewed on January 25, 2011.